Neurology Marathon

Neurology Marathon
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(tensorflow) #1

For those who love neurology, it’s time to START A NEUROLOGY MARATHON! Press reply to post your answers and new questions.

Firstly, ground rules:

  1. As the name suggests, only neurology questions are allowed
  2. When you answer Question (n), you should post Question (n+1). Otherwise you’ll get 0.5 points and a moderator will post the next one.
  3. If a question isn’t answered 7 days after it was posted, then the poster should post a new question. If someone answers the original question, it also counts.
  4. Answer the question and stay on topic. Irrelevant posts will be moved.
  5. First to 11 points wins. The moderator will post a sorted result table after every 5 questions.

So let’s begin!

Question 1:


(Jun Dai) #2

Cadasil …


(Jun Dai) #4

65yo M with Symmetrical Proximal weakness
List 12 differentials


(Hao Tran) #5

14 DDx for symmetrical proximal myopathy

Common conditions - all Endocrine (4):

  1. DM
  2. Hypothyroidism/Hyperthyroidism
  3. Hyperparathyroidism
  4. Pituitary - Addisons
  5. Cushing’s

Less common conditions (3):

  1. Inflammatory Myositis (Dermatomyositis, Polymyositis, Necrotising Autoimmune Myositis, (Inclusion body myositis - prox limbs / distal arms)
  2. Muscular dystrophy - Duchenne Muscular Dystrophy (disorder of dystrophin)
  3. Metabolic - lipid or glycogen storage disorders

Common Drugs (3):

  1. EtOH
  2. Steroids
  3. Statins

Less common Drugs (3):

  1. Antimalarials
  2. Colchicine
  3. Zidovudine

–> for a 65M i would consider that common things occur commonly, hence the 5 DDx for Endocrine causes and 3 DDx for common drugs.


(Hao Tran) #6

Next - what are the metabolic causes of stroke? Give common vs. uncommon. How do they clinically manifest?


(Jun Dai) #7

Fabry disease is a rare storage disorder that can cause stroke. Strokes are usually in posterior circulation. Other manifestations of Fabry include hypertrophic cardiomyopathy, renal disease

Other metabolic causes of stroke include mitochondrial disorders e.g. MELAS


(Jun Dai) #8

55yo M with impaired light touch amd vibration sensation to midshin bilaterally. Other aspects of his lower limb neuro exam were NAD. List 30 differentials